Phosphatidylcholine PPC For KidsNutrasal, Inc.
Phosphatidylcholine PPC For Kids

Is Polyenyl-phosphatidylcholine (PPC) the Missing Ingredient in Your Child’s Nutrition Regimen?

Phosphatidylcholine (PC) is essential nutrition and a necessary building block for life.  It may also be the missing ingredient in your child’s nutrition regimen. PPC has a very long and well documented history and all the evidence suggests that phosphatidylcholine is an incredibly special molecule that is critical to good health.

Phosphatidylcholine has been around since the beginning time and actually predates life as we know it. But it wasn’t until 1953 that highly purified pharmaceutical grade lecithin (PPC – Polyenylphophatidylcholine) made its debut as a registered drug to treat liver disease.  A few years later PPC would be registered again as a new drug to treat lipid disorders and cardiovascular disease. Highly purified PC has now been available as a registered drug for over 70 years and billions of doses are sold every year throughout Europe, Russia, Asia, and the Middle East.

Phosphatidylcholine is the primary active ingredient in lecithin. And lecithin like many products has varying degrees of quality that determine its cost and effectiveness. The cost and most important the therapeutic value of lecithin will greatly depend on the purity and concentration of phosphatidylcholine in the lecithin you decide to use.

The Purity of PC and Concentration of DLPC Makes a Difference in the Therapeutic Effectiveness

Phosphatidylcholine Comparison Chart

These distinctions become important when evaluating the administration and therapeutic effectiveness of lecithin and PC. The short explanation is that a higher concentration of PC delivers more of the primary active ingredient responsible for its therapeutic value and better results.

Standard Lecithin and Standard Triple Strength Lecithin (PC), which is the PC grade available in stores is considered a good source of choline in most cases and an aid to good health.  However, the research is very clear that PC does not become more therapeutically active until it is highly purified to a 76% PC Grade or Higher.

Phoschol PPC is 100 Percent Purified and pharmaceutical grade PPC and is the Gold Standard.  PhosChol has been available through doctors and healthcare professionals for over 35 years in the United States, and nearly 200 million doses have been sold directly to healthcare practitioners in the United States alone. PhosChol PPC is the leading professional brand of Pharma Grade PPC and is unsurpassed in quality and results.

What makes PhosChol PPC so special is that it contains the highest concentrated source of 1,2 dilinoleoylphosphatidylcholine (DLPC), the primary active ingredient responsible for its superior therapeutic efficacy. DLPC is the Holy Grail of the PC Family and PhosChol PPC is the only dietary supplement available that can deliver a therapeutic dose of DLPC.

PPC/DLPC has been thoroughly investigated in several diseases, especially in liver disorders, dyslipidemia and atherosclerosis, diabetes associated sequelae, and gastrointestinal inflammation, but also in skin disorders, renal and lung disorders, gestosis, and in certain neurological disorders. Overall, more than 400 clinical studies involving 15,000 plus patients and more than 1,000 pharmacological investigations have been conducted.

In general, PC works as a cell membrane therapeutic and by improving cellular metabolic functions it effects many other physiological changes fundamental to health.

The studies indicate that administering a therapeutic dose of PPC that is high in 1,2 Dilinoleoylphosphatidylcholine (DLPC), the high energy structural and functional elements of all biological membranes (e.g., of cells, blood corpuscles, lipoproteins, surfactants), are incorporated preferentially and are of critical importance for/as:

  • Cellular differentiation, proliferation, repair, and regeneration
  • Activity and activation of membrane-bound proteins such as of enzymes (e.g., of Na+-K+-ATPase and lipoprotein lipase) and of receptors
  • Transport of molecules through cell membranes
  • Membrane-dependent metabolic processes between the intracellular and intercellular space
  • Donator of polyunsaturated fatty acids (PUFA) as precursors of eicosanoids source of second messengers in cell signaling (e.g., of diacylglycerol)
  • Phosphate donator (e.g., for ATP formation)
  • Fat emulsification in the gastrointestinal tract and as an emulsifier in the bile
  • Erythrocyte and platelet aggregation properties
  • Immunological reactions on a cellular level
  • Restructuring of mitochondria and improving mitochondria function and cell respiration

PC is an Essential Building Block for Life

Phosphatidylcholine’s critical role in life cannot be overlooked. The molecule is indeed an essential building block for life. Without PC to form functioning cell membranes all life as we know it could not exist.  Phosphatidylcholine is truly miracle molecule that supports the formation, proliferation, and healthy function of every cell in our body.  As a cellular organism made up of approximately 50 Trillion Cells, PC is in high demand to make, repair, restructure and regenerate every cell in our body in order for it to function properly. Indeed, there are very few molecules on this planet as essential to life as phosphatidylcholine.

PPC Essential Building Blocks for LIfe

PhosChol PPC is the purest and most highly concentrated form of phosphatidylcholine available. In fact, the National Research Council of Canada conducted an independent study of the dietary supplement market and determined that PhosChol stands alone as the only dietary supplement to contain an Oil Seed Medicinal (PPC) registered in two pharmaceutical products for liver disease and heart disease.

“Because it [Phosphatidylcholine/DLPC] is part of the membrane sandwich along with the right fatty acids and other nutrient, it is one of the reasons some people will never get better…because no one recommended it.”  Dr. Sherry Rogers, Detox or Die

A Special Role in Liver Health

Well over 200 Clinical Studies have been done in liver diseases.  Many of these are controlled, multi center, double bind and placebo studies. The data has been consistent in demonstrating that EPL and PPC is a therapeutic powerhouse.

An independent paper published in the Alternative Medicine Review, determined that PPC was a Superior Liver Protectant with more than two decades of clinical trials demonstrating PPC protects the liver against damage from alcoholism, pharmaceuticals, pollutant substances, viruses, and other toxic influences.

Holistic Anti-Ageing Benefits

The amazing holistic health benefits of PPC might be why Dr. Nicholas Perricone, in his book the Perricone prescription, referred to PPC as the “Fountain of Youth” and the “best anti-aging miracle” he has found.

Because PPC plays both a physiological and holistic role and effects the metabolic function of every cell and organelle in your body; it is by far one of the most important ingredients you can add to your regimen to improve health.

Dr. Sherry Rogers highlighted this critical point in in her book Detoxify or Die when she said, “Because it [Phosphatidylcholine/DLPC] is part of the membrane sandwich along with the right fatty acids and other nutrient, it is one of the reasons some people will never get better…because no one recommended it.”

PPC For Children and Young Adults 

PhosChol PPC is considered innocuous and safe to administer to children from newborns to young adults. PPC is a safe and biologically active form of Choline and has been used safely in a variety of in utero and post-partum clinical studies to measure the effects of choline on brain and organ development, cognitive function and memory, and mood and depression. Studies report that PPC is well tolerated with no known side effects, interactions, or contraindications.

Because Childhood Disorders present in such unique and individualized ways it is difficult to design clinical studies with reliable and repeatable results. For this reason, there are no large controlled, multi-centered, double blind, placebo-based studies for any Spectrum Related Disorders.

Over the past 20 years, there has been a considerable increase in interest from physicians and parents regarding the use of PPC to address a variety of childhood health concerns. Both doctors and parents have reported that adding PPC to a nutritional regimen resulted in noticeable improvements in energy, responsiveness, mood and disposition, an increased ability to communicate, interact and show affection, among others.

We recognize that every child and childhood illness in unique and that PPC may not produce the same results in every child, however, a significant amount of positive feedback over 20 years of administration suggests that adding PPC may be beneficial when added to an existing regimen.

The Importance of Phosphatidylcholine in Childhood Health

The importance of phosphatidylcholine in childhood health has been studied, reported on, and written about in books, newsletters, and blogs for years. Many of these health concerns and the use of phosphatidylcholine as an essential ingredient to address these childhood health concerns are discussed in detail in Dr. Kenneth Bocks Book “Healing The New Childhood Epidemic (the 4-A Disorders) and in Kelly Dorfman’s, MS, LSN, book “Curing Your Child with Food”.   We highly recommend these two books for the quality of their research and their practical results driven approach.

Based on the available clinical data, we believe PhosChol is helping in several major areas:

Extensive clinical and pharmacological data available from a broad range of pathologies suggests purified PPC/DLPC plays a fundamental role in the Gut – Liver – Brain Connection discussed by many healthcare practitioners in this field.

Across many of the New Childhood Ailments we have identified several areas of interest in which the biological activity of PPC/DLPC has been clinically studied and matches up to the symptoms and pathology common to many who suffer from these health concerns.

These areas include: *

  • A cell membrane therapy
    • Enhanced membrane dependent metabolism
    • Enhanced receptor capabilities
  • Liver Function and Detoxification
    • Restored SAMe and Enhanced Glutathione Production
    • Improved Methylation (Transmethylation and Transsulfuration)
  • Leaky Gut Repair
    • Integrated into the gastric mucosa to repair leaky gut
    • Significantly lowers ulceration under treatment of NSAID’s
  • Enhanced Neurological Processes
    • Increased acetylcholine synthesis and neurotransmission
  • Improved Mitochondria Function
    • Restructures and repairs the Double Membrane of Mitochondria

Conclusion

A broad range of pharmacological investigations, clinical trials, and other available data on PPC and its different and unique modes of actions demonstrate that PPC acts primarily through its influence on membranes.

As cell membrane damages occur in many disorders, PPC’s therapeutic approach is both physiological and holist and can be used alone or as an adjunctive therapy.

#1 Healthcare Practitioner Brand Since 1982

Phosphatidylcholine PPC a Potential Therapy for NAFLDNutrasal, Inc
Phosphatidylcholine PPC a Potential Therapy for NAFLD

Non Alcoholic Fatty Liver Disease – NAFLD

A Disease of Emerging Identity and Importance

NAFLD is now the most common liver disorder in the world with a prevalence rate ranging from 6% to 35% of the general population, and a median rate of 20%.  There is strong evidence that the occurrence of NAFLD is increasing and is likely to correspond to regional trends in over nutrition, obesity, type 2 diabetes, and metabolic syndrome.

NAFLD equally affects both sexes. Although, it is most common in over-weight and obese persons and in patients with adult onset (type 2) diabetes, it can also be present in lean persons and in overweight children and adolescents.

NAFLD represents a spectrum of hepatic disorders characterized by macrovesicular fatty liver, with histology ranging from steatosis (fatty liver) to non-alcoholic steatohepatitis (NASH), to NAFLD-associated cirrhosis and to hepatic cancer. In addition to being a disease of the liver, NAFLD is associated with an increased risk of type 2 diabetes mellitus, chronic kidney disease, and cardiovascular disease, with the latter being the most common cause of death in patients with NAFLD.

It is the risk of progression from fatty liver as a benign disorder to liver disease with inflammation, fibrogenesis and cell death that makes NAFLD a medical challenge, as an established therapy is not yet available.

One of the compounds in the focus of investigation is polyenylphosphatidylcholine (PPC) from soybean (Phoschol®). As the non-toxic PPC is widely used in membrane-associated hepatic diseases (for example by alcohol, medicaments, and pollution), its effectiveness on NAFLD was also anticipated.

The use of highly purified phosphatidylcholine as EPL (essential phospholipids – 76% + PC) and PPC (polyenyl-phosphatidylcholine – 100% PC) is well established. Hundreds of clinical studies and thousands of pharmacological investigations confirm PPC is a superior liver protectant. And seventy (70) years of use worldwide and billions of doses administered for liver and cardiovascular disorders has clearly demonstrated that PPC is a safe and effective therapy or adjunctive therapy.

PPC described in a leading medical textbook: Hepatology

“Based on these pharmacological and clinical data, PPC would appear to be the drug of choice for significantly reducing or abolishing fatty liver of different origin, e.g. due to alcohol, or obesity, even if the causing noxa cannot be eliminated, as is the case with diabetes-associated steatosis.”

Dr. E. Kuntz and Dr. H.-D. Kuntz: Hepatology – Textbook and Atlas-.3rd Edition, 2008

New Study Highlights the Significance of PPC as a Potential Therapy for NAFLD

“Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities”

Study Objective

“Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal results of liver function tests. Earlier research showed that polyenylphosphatidylcholine (PPC) has hepatoprotective effects and thus can be used for the treatment of NAFLD and the prevention of its progression. Accordingly, the aim of this observational study was to evaluate if PPC administered as adjunctive therapy in routine clinical practice can effectively improve liver function tests of NAFLD in Russian patients with associated metabolic comorbidities.”

Study Highlights

What is already known about this subject?

►► “Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal results of liver function tests.

►► Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), which are markers of liver injury, are still considered as useful surrogate measures of NAFLD for clinical practitioners; recently, however, their diagnostic value has been challenged.

►► Previous research has indicated that polyenylphosphatidylcholine (PPC) might have a positive influence on liver enzyme levels, as well as on serum lipid profile.

What are the new findings?

►► PPC administered as adjunctive therapy in patients with NAFLD with metabolic comorbidities consistently lowered AST, ALT and GGT levels, irrespective of the nature and number of associated comorbidities.

►► Although a low rate of achieving total cholesterol levels below 5.0 mmol/L was noted at the end of the study in the overall patient population, significant improvements in lipid parameters were observed in both patients receiving PPC only and in those receiving PPC in addition to statins and/or fibrates.”

 

How might it impact on clinical practice in the foreseeable future?

►► “PPC has a promising role in the management of both NAFLD and its extrahepatic manifestations, including abnormal liver enzyme and lipid levels.

►► Liver enzymes can be useful markers for monitoring the progression of NAFLD over time. There is a need for further investigation on the association of liver enzymes with NAFLD, which might help improve the diagnosis, management, and risk prediction of NAFLD progression and provide a more accurate indicator for chronic metabolic liver injury.

►► Individualized intervention strategies should be adopted in Russia to improve the management of patients with NAFLD with associated dyslipidemia.”

Study Conclusions

“Adjuvant treatment with PPC resulted in consistent improvements in liver enzymes in patients with newly diagnosed NAFLD and associated metabolic comorbidities. The results of the study suggest that PPC adjunctive therapy is effective in improving liver function markers of NAFLD in patients with associated metabolic comorbidities and that PPC might have a positive impact on serum lipid profile.”

References:

  1. Maev IV, Samsonov AA, Palgova LK, et al. Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia, BMJ Open Gastroenterology, 2020;7:e000368. doi:10.1136/bmjgast-2019-000368
phosphatidylcholine supplements do not raise TMAONutrasal,inc.
phosphatidylcholine supplements do not raise TMAO

Recent studies confirm (PC) phosphatidylcholine supplements do not raise TMAO (trimethylamine N-oxide).

Nutrasal has long maintained that dietary choline in the form of Highly Purified Phosphatidylcholine (PPC) was not increasing TMAO, platelet aggregation and CVD. We have advocated for the continued administration of PPC as a good source of biologically preferred choline and phosphatidylcholine as a cell membrane therapeutic and for use in liver, heart, brain and gut health, among others.

We based our position on the available TMAO research at the time which we believed to be tenuous at best and significantly biased in favor of creating misleading and sensational results. When analyzing the initial TMAO research we quickly realized that the body of work was limited, and it specifically never included phosphatidylcholine supplementation. Clinical studies never established a correlation between phosphatidylcholine and TMAO and any inference or assertion to PC administration contributing to TMAO and CVD was never supported by research. When we compared the limited TMAO data to the depth and breadth of clinical and pharmacological research confirming the many positive health effects and therapeutic benefits of PC it became reasonable to conclude that the administration of highly purified PC should be continued.

Now, more recent studies published in Nutrients and The American Journal of Clinical Nutrition support our conclusion. 

Phosphatidylcholine Background

The use of highly purified phosphatidylcholine has a very long and successful track record. Hundreds of clinical trials and an even greater number of pharmacological investigations have confirmed the holistic, physiological, and therapeutic effectiveness of PPC in heart disease, liver disease, brain development, cognitive and memory function, and gut health, among other indications.  Additionally, PPC has been prescribed worldwide since 1953 for liver disease and heart disease. PPC has consistently demonstrated positive results with an outstanding safety profile. Billions of doses have been administered over 70 years and no significant side effects, contraindications, or interactions are known or reported.

Physiological role of Phosphatidylcholine

Phosphatidylcholine is the main active component of lecithin and a metabolic precursor for choline. PPC is the 100 percent active form of lecithin/PC. Phosphatidylcholine is important for the structural integrity of cell membranes, cholinergic neurotransmission, transmembrane signaling, methyl metabolism, and lipid-cholesterol transport and metabolism. Choline is a precursor for phosphatidylcholine, sphingomylin, platelet-activating factor, betaine, and other phospholipids.  Phosphatidylcholine is the body’s storage mechanism for glycerophosphocholine (GPC) and for Choline. Choline speeds the synthesis and release of acetylcholine, an important neurotransmitter involved in numerous important functions in the body.

Choline is an essential nutrient since the body’s own production of choline is not always sufficient to meet human requirements for choline. Especially as we age and the need for more choline to form PC for cell membrane formation, repair, restoration and regeneration is in much higher demand.

Phosphatidylcholine is a biologically preferred dietary source for choline and an essential building block for all cell membranes and for life. Without PC cell membranes can not form and without cell membranes all organic life as we know it could not exist.  PC is fundamental to good health and to life.

Studies of Interest:

As study conducted by researchers at Cornell University and Utah State University evaluated the “Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men.”  The author’s concluded that high TMAO was more likely caused by choline bitartrate supplementation and not Phosphatidylcholine. (1)

Significant Clinical Findings and Discussion:

  • Consumption of choline bitartrate, but not phosphatidylcholine, leads to greater TMAO production and that gut microbiota composition contributes to alterations in TMAO response to choline bitartrate.
  • Choline bitartrate yielded 3-times higher plasma TMAO AUC and 4.4-times higher plasma TMAO maximum increase from baseline compared to phosphatidylcholine and no choline control.
  • TMAO change from study-baseline and AUC after phosphatidylcholine consumption
  • did not differ compared to that of no choline control despite higher circulating and urinary free choline concentrations.
  • Given that phosphatidylcholine is the major form of choline in food, the absence of TMAO elevation with phosphatidylcholine counters arguments that phosphatidylcholine should be avoided due to TMAO-producing characteristics.

A study conducted by the Lerner Research Institute and the Cleveland Clinic; and published in The American Medical Journal concluded dietary choline from eggs and supplemented choline in the form of Phosphatidylcholine (PC/PPC) does not raise TMAO or contribute to platelet aggregation. (2)

Significant Clinical Findings and Discussion:

  • Daily dietary free choline supplementation (especially choline bitartrate) for 28 days significantly raised fasting trimethylamine-N-oxide (TMAO) levels in plasma and urine, and increased platelet aggregation responsiveness to submaximal agonist.
  • The daily consumption of eggs or phosphatidylcholine, containing an equivalent total choline content to the free choline, failed to increase TMAO or platelet aggregation.
  • The form of choline in dietary nutrients differentially contributes to gut microbiota-dependent TMAO generation and systemic TMAO levels.

Conclusion

Nutrasal is of the opinion that supplemented phosphatidylcholine as a choline donator and cell membrane therapeutic does not contribute to TMAO increase, platelet aggregation and CVD.

Considering 70 years of safe and effective administration, thousands of clinical and pharmacological studies confirming the therapeutic benefits of phosphatidylcholine supplementation, and the most recent randomized and controlled studies establishing phosphatidylcholine supplements failed to increase TMAO and platelet aggregation; there should be no objection in using phosphatidylcholine as a dietary supplement.

PhosChol is the leading practitioner brand of purified PC since 1982.  For more information visit: Doctor Recommended PhosChol (nutrasal.com)

References:

  1. Choe C. E. et al. Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men, Nutrients July 25, 2020
  2. Wilcox, J., Skye, S. M. et al. Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial. The American Journal of Medicine, Volume 134, ISSUE 9, P1160-1169.e3, September 01, 2021
PPC and GPC Choline Source
PPC and GPC Choline Source

Phospholipid Choline Sources are Biologically Preferred Sources of Choline

Choline and especially Phospholipid Choline is considered an essential nutrient and is one of the few nutrients allowed by the Food and Drug Administration and European Food Safety Authority to make health claims. Choline has many important roles in the healthy structure and function of the human body and is recognized worldwide as a critical nutrient in prenatal and infant nutrition. New health claims describe choline’s role in reproductive development, brain develop and memory function throughout life, normal lipid metabolism and cardiovascular health, homocysteine metabolism and liver function, among others. A broad and deep body of research also reveals important metabolic synergies with other essential vitamins and other nutrients.

Choline is life giving in that it is critical for making phosphatidylcholine for cell membrane formation, structure, repair, regeneration and proliferation. As cellular organisms consisting of some 50 trillion cells held together by Cosmic Biological Glue, choline and phosphatidylcholine especially become critical building blocks for all life.  In fact, without these two very special molecules cell, tissues, organs could not be formed and indeed all organic life as we know it would not exist.

PPC Essential Building Blocks for LIfe

Phospholipid choline in the phospholipid and phosphoryl choline forms are blood stable (stable in the water phase) and biologically preferred sources of the critical nutrient.

Choline in other forms and at higher doses is not stable. What isn’t immediately used for acetylcholine (an important neurotransmitter) synthesis is ultimately converted in the body to phosphatidylcholine for safe and stable storage and to be used for cell membrane formation and repair.

When the body is calling for a choline source it will sacrifice phosphatidylcholine by removing the two fatty acids (lipids) to create GPC (Glycero Phospho Choline), which is the water-soluble head group (phosphorus, choline, glycerol backbone) of the phosphatidylcholine molecule. The GPC molecule is then further broken down to make choline available for acetylcholine synthesis and neurotransmission.

Choline, phosphatidylcholine (PC) and Glycerophosphocholine (GPC) are in a constant state of flux, forming and reforming, and working synergistically to keep our 50 trillion plus cells metabolically stable and functioning properly.

Dr. Perricone wrote in his book the Perricone Prescription that in his “search to find the fountain of youth…he thinks he’s found it in PPC”. We strongly agree! And it makes perfect sense when you look at the metabolic importance and the life-forming necessity of choline and phosphatidylcholine.

Life happens on the cell membrane and without choline to make phosphatidylcholine for cell membrane formation, respiration, repair, restructure, and regeneration; proper cell function and metabolism is soon replaced by dysfunction and disease.

As manufacturer of the most highly purified and pharmaceutical grade PPC and GPC products on the market and the leading healthcare practitioner brand, WE LOVE THIS STUFF. And we are absolutely convinced that everyone on this planet interested in good health should be supplementing with PPC or GPC on daily basis.

The sad reality is that our modern diets do not provide enough dietary choline. The two most abundant sources of choline are liver meats and egg yolks. Now we all know how we feel about eating liver with fried onions, and egg yolks unfortunately have received such a bad rap over the last 40 years that most folks avoid them at their own peril (approximately 4 yolks per day would be great).

We understand our inherent bias for all things phospholipid, so if you are interested in learning more from an outside source, a recent article by Prof. Gene Bruno published in the Vitamin Retailer Magazine does a nice job of describing the importance of GPC. You can read the article here: https://vitaminretailer.com/phospholipid-choline-a-natural-brain-and-body-beneficial-choline-source-for-all-stages-of-life/

If you are interested in adding a preferred biological source of choline to your health regimen, Nutrasal manufacturers PhosChol PPC and Cerebra GPC, the two highest quality pharmaceutical grade forms available.

Click on the Images to Learn More About these 2 Top Selling Phospholipid Choline Sources

PhosChol PPC and Cerebra GPC are the Leading Pharmaceutical Grade and Healthcare Practitioner Brands in the United States

PhosChol PPC Vet
Purified PC for Your Pets Good Health

PhosChol PPC Vet is 100% Purified Pharmaceutical Grade Phosphatidylcholine

Formulated Exclusively for Pets and Recommended by Veterinarians as the Best Source of Pure PPC

PhosChol PPC VET has been clinically studied by some of the best schools of veterinary medicine and PhosChol and PhosChol Vet is the preferred choice of veterinarians for treating liver disorders, especially canine liver disorders related to copper toxicity. In fact, PhosChol is the only phosphatidylcholine product recommended in the Merck Veterinarian Manual for treating canine liver disorders.

PhosChol PPC Vet uses the identical pharmaceutical grade phosphatidylcholine as our Human Version of PhosChol liquid Concentrate, which for over 35 years continues to be the #1 Selling Healthcare Practitioner Brand!

In fact, since 1982 well over 100 million doses (almost 200 million) have been administered by doctors in the United States alone.  PhosChol stands alone as the best source of purified PPC. And, PhosChol delivers the highest concentrated source of  the primary active ingredient 1,2 DLPC, which is responsible for it’s superior results.

Since 1953 highly purified PC has been prescribed for liver health and pharmaceutical grade PC continues to be a registered product in over 50 countries for treating various liver disorders.

Purified PC has been proven safe and effective for over 70 years and you can be sure the same quality, safety and efficacy applies to your favorite fury family members as well.

How Does it Work

All life as we know it happens on the cell membrane and purified PPC (PhosChol) provides the building blocks essential to cellular membrane, formation, repair, regeneration and function.

Like bricks of a wall, cellular membranes act as barriers to protect each cell and organelle in the human and animal body, maintaining cellular structure, function and co-operation.

Cell membranes are an essential building block for life as cells, tissues, organs and ultimately an organism cannot be formed without them. Without PC and cellular membranes, life as we know it would not be possible.

PPC Essential Building Blocks for LIfe

Phosphatidylcholine clearly plays a vital role in human and animal life. Its role is even more important when harmful environmental conditions (i.e. tainted food, cleaning chemicals on paws, etc.) lead to cell membrane damage. When cell membranes become damaged and rigid due to higher levels of inflammation and oxidative stress, cell function/metabolism decreases, and good health is replaced by dysfunction and ultimately disease.

When membrane damages are present, PC is in high demand to help form, proliferate, restore and regenerate cell membranes and to enhance membrane-dependent metabolism.

Providing a dietary source of purified PPC to your pet may be one of the best things you can do to promote and preserve good health.

PhosChol PPC Vet is Clinically Proven Safe and Effective Liver Support for Your Pet

We are confident your pet is going to appreciate the new great taste, liposome delivery system and the results!

PPC VET uses the exact same same pharmaceutical grade PPC found in our PhosChol “People” products.

There are 48,000mg of purified PPC per 8oz and bottles which equates to 48 – 1000mg doses.

The dosing chart found on the bottle (dosing based on clinical study recommendations) makes it easy to give to any sized pet…from 5 lbs. to 150+ Lbs.

Covid Mortality and Vitamin D3
Covid Mortality and Vitamin D3

A Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3

Results of a Systematic Review and Meta-Analysis – Peer Reviewed – Published in Nutrients October 2021

The authors main goals with this Review and Meta-Analysis are to support the following statements:

  • The correlation between low Vitamin D blood levels and severity/mortality of Covid-19 is causal.
  • There exists a natural blood level of vitamin D3 in the range of 50 ng/ml needed to avoid most severe courses of SARS-CoV-2 infections.
  • The current recommendations of health organizations (e.g. WHO) for Vitamin D blood levels  (20 to 30 ng/ml) as well as the recommendations for daily Vitamin D supplementation are much too low to fight against Covid-19.

Authors

Lorenz Borsche 1,*, Bernd Glauner 2 and Julian von Mendel 3

1 Independent Researcher, D-69117 Heidelberg, Germany
2 Independent Researcher, D-72076 Tübingen, Germany
3 Artificial Intelligence, IU International University of Applied Sciences, D-99084 Erfurt, Germany

Study Abstract

Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic. Methods: Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex, and diabetes. Data were analyzed using correlation and linear regression. Results: One population study and seven clinical studies were identified, which reported D3 blood levels preinfection or on the day of hospital admission.

The two independent datasets showed a negative Pearson correlation of D3 levels and mortality risk (r(17) = -0.4154, p = 0.0770/r(13) = -0.4886, p = 0.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/mL (17.4–26.8), and a significant Pearson correlation was observed (r(32) = -0.3989, p = 0.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL D3.

Conclusions: The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

Vitamin D3 and Angiotensin System

The information provided in this paper is an extraordinarily detailed compilation and examination of the most recent substantial global data and the high-quality evidence demonstrating a direct causal link between lower Vitamin D levels and poorer Covid 19 Outcomes.  Written by Dr. Laura LL Benskin, the paper is peer reviewed and available on Research Gate.

The role of vitamin D in adaptive immunity is increasingly recognized & believed to have critical immunomodulatory effects.

The paper dives deep into the:  

  1. Classification of vitamin D levels and why low levels are common
  2. Recommended serum levels and intake goals from organizations and governments
  3. Biological Plausibility: How vitamin D’s known mechanisms of action relate to Covid-19
  4. Correlational evidence regarding serum vitamin D levels and Covid-19 outcomes
  5. Evidence based on individual data (chart reviews)
  6. Evidence based on meta-analyses and systematic reviews
  7. Evidence that vitamin D is a causal factor in poor Covid-19 outcomes
  8. Specific recommendations for Vitamin D supplementation to improve Covid-19 outcomes

Paper Abstract

Most of the world’s population has vitamin D levels which are suboptimal for healthy immune system function. Recent recommended goals are far higher than legacy guidelines, which are based entirely upon promoting bone health, rather than on supporting all the many other functions of vitamin D. Vitamin D strengthens the innate immune response, decreasing the likelihood of infection from SARS-CoV-2 exposure.

Vitamin D also regulates the adaptive immune system and inflammation. Thus, with appropriate levels, infected persons have a reduced likelihood of developing hyperinflammatory (severe) Covid-19 (the cytokine or bradykinin “storm”). Many experts have noted that vitamin D plays a role in preventing every one of the disorders associated with severe Covid-19. In addition, the risk factors for getting severe Covid-19 are identical to the risk factors for becoming vitamin D deficient. Evidence of a link between low vitamin D levels and poor Covid-19 outcomes is robust, including numerous population and individual correlational studies, causal modeling, prospective cohort intervention studies, and randomized controlled trials.

About the Author

Dr. Linda LL Benskin, PhD, RN, is an independent researcher for sustainable health solutions for remote and conflict areas of tropical developing countries and the Research, Education, & Charity Liaison for Ferris Mfg. Corp. (makers of PolyMem dressings) in Ft Worth, TX.

Her interest in wound-related inflammation control led to a study of vitamin D’s role in the Covid-19 pandemic. Dr. Benskin authored A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency, which has been cited by over 70 other author groups. She is currently conducting a randomized controlled trial of improvised dressings for wounds in the tropics.

Disclaimer:

We are providing this information for research purposes only. We are not endorsing any products associated with this information. This paper and statements herein have not been evaluated by the Food and Drug Administration. This paper and our products are not intended to diagnose, treat, cure or prevent any disease, and no such claims are being made.

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Nutrasal, Inc. 2020

Purified Polyenylphosphatidylcholine (PPC) Increases Host Defenses and Boosts the Immune System*

Did you know that highly purified polyenlyl-phosphatidylcholine (PPC) (PhosChol) plays an important role in your body’s immune system?

Many health minded individuals and proponents of good nutrition and dietary supplements are familiar with the use of PPC in liver health, brain health, and cardiovascular health, among others.  And, it is fairly well known amongst “Functional and Complimentary” healthcare practitioners that highly purified PC has been used as a registered drug to treat liver and cardiovascular diseases since the 1950’s.  Thousands of studies dating back to the 1950’s, as well as more recent clinical studies continue to demonstrate just how important and powerful PPC is to improving health and wellness.

However, despite all the extensive research available on PPC and a patent issued for its use in the “PREVENTION AND TREATMENT OF MICROBIAL INFECTION BY PHOSPHOGLYCERIDES”, (Vitale, Joseph J. Pat. No: 5,135,922) the public remains unaware of this multifaceted and powerful immune boosting agent. *[1]

Below are just a few examples to demonstrate the depth and breadth of the holistic benefits of PPC administration and how it structurally and functionally works to improve your health. * [2]

  • PPC is a high energy structural and functional element of all biological membranes (e.g. of cells, blood corpuscles, lipoproteins, and surfactants
  • PPC is indispensable for cellular differentiation, proliferation, repair, and regeneration
  • PPC is important for the transport of molecules (nutrients and metabolic by products) through cell membranes
  • PPC controls membrane-dependent metabolic processes between the intracellular and intercellular space
  • PPC maintains and promotes the activity and activation of membrane-bound proteins such as of enzymes (e.g. Na+-K+-ATPase, lipoprotein lipase) and of receptors (e.g. of insulin)
  • PPC contains polyunsaturated fatty acids to be used on request as precursors of cytoprotective prostaglandins and of other eicosanoids
  • PPC contains choline to be used on request in certain neurological processes such as for the synthesis of the neurotransmitter acetylcholine
  • PPC is a source of second messengers in cell signaling (e.g. of diacylglycerol)
  • PPC contains phosphate e.g. for ATP formation
  • PPC participates in fat emulsification in the GI-tract and in the bile
  • PPC codetermine erythrocyte and platelet aggregation
  • PPC restores depleted S-adenosylmethionine levels to normal and increases glutathione production in the liver
  • PPC influences immunological reactions on the cellular level

The Role of PPC in the Immune System: *

The body has several ways in which to defend itself against infectious agents or pathogens. There are components of our bodily defenses that are not part of the Immune System such as our skin, which acts as an external barrier to pathogens.  And there are internal barriers such as the mucous barriers that are found in our pulmonary and gastrointestinal systems.

Additionally, there are cells within our circulatory system that also defend against infectious agents and may be divided in to immune and non-immune cells depending on their origin. Nonetheless, both types may interact in a synergistic manner to “kill” or destroy the infectious agent or the infected cell.

One cell type that Purified Polyenyl-phosphatidylcholine has been shown to activate, or to enhance its “killing” ability is the Polymorphonuclear Leukocyte, a non-immune cell type. These cells are critical component of our “Innate” defense systems. They play an important role in defending against and succumbing to opportunistic infections to which individuals with suppressed and/or altered immune functions weakened by age, malnutrition, illness or by drugs being used to treat other various illnesses may be susceptible.  [1]

Opportunistic infections are those caused by infectious pathogens (e.g., fungal, bacterial or viral) that are more likely to occur in those who may be chronically ill, or who are on medications that suppress their host defenses or immune responses. Host defenses include the skin, mucous membranes of our mouth, lungs, and gastrointestinal tract as well as certain cells circulating in our blood stream including polymorphonuclear leukocytes or PMNS. [1]

As earlier stated, Purified Polyenyl-phosphatidylcholine has been shown to “activate” certain cells of the immune system including those that can produce antibodies and others (Natural Killer (NK) Cells) that can “kill” infected cells (NK Cell Activity). [1]

According to Vitale, PPC is the preferred phosphoglyceride for activating positive immunological responses and what makes it an effective therapeutic and prophylactic agent for bacterial, yeast protistan and viral infections. [1]

Liver Immunobiology and the Importance of PPC in Liver Health and Function. *

Experimental and clinical results support the assumption that the therapeutic application of PPC has protective and even curative and regenerative effects on the biological membranes of sinus endothelial cells and liver cells.

The hepatoprotective effects of PPC have been confirmed when compared to controls and were more pronounced the earlier EPL was administered: [2]

  • Structures of liver cell membranes were normal or largely normalized
  • Fatty infiltrations and hepatocyte necrosis were diminished or eliminated
  • Positive corresponding data were found for lipid peroxidation, transaminase and cholinesterase activity, and for serum lipids; and overall liver cell metabolism increased
  • The increase of RNA and protein synthesis and of the liver cell glycogen content indicated a stimulation of the liver cells
  • Reduced collagen production, collagen/DNA ratio and liver hydroxyproline indicated a reduced formation of connective tissue

Liver Involvement in Adaptive Immunity

The liver is responsible for several important functions in innate and adaptive immunity. Contributions to the innate immune system include production of acute phase proteins, nonspecific phagocytosis of particles, nonspecific pinocytosis of molecules, and nonspecific cell killing. Hepatic involvement in innate immunity contributes to the systemic response to local inflammation, clearance of particles and soluble molecules from the circulation, and killing of invading cells such as neoplastic cells. Liver involvement in the adaptive (specific) immune system includes deletion of activated T cells, induction of tolerance to ingested and self-antigens, extrathymic proliferation of T cells, and deletion of many of the signaling and effector molecules. Hepatic involvement in adaptive immunity allows clearance of activated T cells and signaling molecules following inflammatory reactions and promotes immunologic tolerance toward potentially antigenic proteins that are absorbed from the intestinal tract. The liver is a major site of extrathymic T cell development, which assumes increasing significance with aging in mammals. Perturbations in hepatic structure or function can result in significant ramifications in both the innate and adaptive immune systems. [3]

In addition to serving as an arena for several immune-mediated pathologic processes, the normal liver has continual direct involvement in adaptive immune system.  Major facets of this involvement            consist of the:

  1. Deletion of activated T cells that originate from inflammatory reactions at any site in the body
  2. Induction of tolerance to ingested and self-antigens
  3. Extrathymic proliferation of T lymphocytes
  4. Disposal of waste molecules that result from immunologically mediated events. The major cellular elements involved in these processes include dendritic cells, macrophages, and various subpopulations of T lymphocytes. [3]

PPC Is Critical to Life and Optimal Wellness*

PPC is a powerful holistic molecule with many benefits, including improved immune function.  Clinical trials and experimental studies have demonstrated conclusively that PPC as a membrane therapeutic effectively liver cell metabolism and alters the lipid composition of certain immune cells, resulting in enhanced host defenses (phagocytosis and NK cell activity).

The discovery that the administration of PPC leads to a series of complex mechanisms triggering NK Activity and the enhancement of phagocytosis and “killing” by PNMs is significant.  This discovery has led researchers to conclude that “clearly the dramatic effect of PPC on the clinical course and outcome of both bacterial and viral infections empirically demonstrates the use and value of PPC and related molecules as effective therapeutic and prophylactic agents for bacterial, yeast protist and viral infections. “ [1]

References:

  1. Joseph J. Vitale, Prevention and Treatment of Microbial Infection by Phophoglycerides, US Patent: 5,135,922, 1992
  2. Karl J. Gundermann, The Essential Phospholipids As A Membrane Therapeutic, Polish Section of European Society of Biochemical Pharmacology, SZCZECIN, 1993
  3. George A. Parker and Catherine A. Picut – Liver Immunobiology, USA Toxicologic Pathology, 33:52–62, 2005

The Information Contained Herein is for educational purposes only.  These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

Copyright © 2020, Nutrasal, Inc.

PhosChol Supports Immune Health

PPC Supports Immune Health and So Much More

Immune Boosting Nano Emulstion D3

This month, Nutrasal is having a special sale on our Super Immune Boosting Liposome and Nano Emulsion 3-pack. They are professionally formulated, high dose immune support systems – for $25 less than usual!

The super absorption and bioavailability of these essential immune support ingredients are made possible with our advanced liposome and nano technology delivery systems. Even better, the formulations are great for both adults and children, with variable dose size options.

Learn some other immune boosting recommendations here!

Better sleep is key

It seems so simple, but sleep deprivation can be an immune system killer and lead to higher levels of stress and anxiety. Studies have shown that people who don’t get enough sleep are more likely to get sick after being exposed to a harmful virus, bacteria, or other opportunistic infection. Beyond that, a lack of quality sleep and increased stress often lead to immune suppression, thus affecting how one recovers from being sick.

Cytokines are key immune response proteins that are activated when the body is under stress or being attacked by opportunistic infections. Getting enough sleep may increase production of these protective proteins, as well as help to regulate their response once activated. Additionally, sleep deprivation has been shown to reduce important infection fighting antibodies, which are key to how well one’s body can control the immune response.

Whole foods are necessary

A great way to increase immune function is to choose healthier, whole foods packed with quality protein sources, good fats, and delicious fruits and vegetables. Increasing the quantity and variety of foods that provide proteins, fats, micronutrients, and antioxidants is crucial and perhaps the most vital thing one can do to bolster the immune system.

Consuming enough nutrients with a healthy, whole foods diet is required for the health and function of one’s cells, including immune cells. The body’s immune response relies on the presence of a variety of micronutrients. They have been identified as critical for growth and function of immune cells such as vitamin C, vitamin D, zinc, selenium, iron, and protein. Diets that are low in these nutrients may require dietary supplementation.

Get that body moving!

Moderate exercise and movement have been shown to have a tremendous impact on immune function. A quick 30 minutes of light to moderate movement like walking, cycling, or swimming a few times a week has been shown to improve health and immune functions. Moving one’s body doesn’t always have to be hard or require a gym.

As the body adapts to the regular exercise, one will find themselves getting stronger, more fit, and even losing a bit of weight. Plus, it has been shown that regular movement leads better sleep patterns and decrease in stress. Remember, even small amounts of exercise will cause you to reap these benefits!

Dietary supplements

Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease, but supplementing with known immune boosting agents such as vitamin D, vitamin C, vitamin B12, zinc, selenium, and magnesium, as well as others, can help fill the nutritional gap and be incredibly beneficial.

If diet, exercise, and sleep just aren’t doing enough, then fortifying one’s diet with known immune boosting supplements may help to support a healthy immune system, and even make a difference in the severity of symptoms when illness does hit.

The most common deficiencies affecting health and immune function are vitamin D3, magnesium, and vitamin B12, all of which can easily be corrected with dietary supplements.

We want to prepare you for these unprecedented times

As the world struggles during these unprecedented times, leading experts, scientists, researchers, and doctors are experimenting and conducting clinical trials using a variety of nutritional interventions and protocols that may help to strengthen immune function and response.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.