Purified PPC (Polyenylphosphatidylcholine) Improves Immune Function and Strengthens Host Defenses*
Unless you are huge PPC fan like we are, you may not know that clinical studies have shown that PPC has a pretty significant interaction with the innate and adaptive immune system and an ability to boost your body’s host defenses and improve immune function. PPC is an extraordinary and essential molecule for life and good health, and if you are using PPC for Liver Health, Brain Function and Neurological Support, Gut Protection, or Lipid Management; you will be happy to know that both your innate and adaptive immune system is benefiting too. Improving immune function is just one of the many “side benefits” of adding PPC to your good health regimen.
Doctors and Healthcare Practitioners have known for over 70 years that PPC plays a special role in cell membrane restructure, repair, and regeneration and metabolism. Life happens on the cell membrane and PPC is the by far the most effective cell membrane therapy available. Hundreds of human clinical studies and more than a thousand pharmacological investigations dating back to the 1950’s, as well as more recent and ongoing studies demonstrate just how important and powerful PPC is to improving cell metabolism and function. PPC is an absolute essential building block for life and good health.
Fun Factoid: Highly purified PC has been available as a prescription medication to treat liver and cardiovascular disease since the 1950’s. It is registered in over 50 countries around the world and billions of doses have been administered over this time. “Phoschol PPC is the only dietary supplement to contain the only oil-seed medicinal to be found in two (2) registered drugs.” Source: National Research Council, Ottawa Canada. Phoschol PPC has been available to Doctors in the United States as a dietary supplement since 1982. It is the leading healthcare practitioner brand, and over 200 million doses have been administered by healthcare professionals in the US alone. www.phoschol.com
Notwithstanding 70 years of continued use, extensive research, and multiple patents including a US Patent for the “PREVENTION AND TREATMENT OF MICROBIAL INFECTION BY PHOSPHOGLYCERIDES”, (Vitale, Joseph J. Pat. No: 5,135,922) the general public remains unaware of this multifaceted and powerful cell membrane therapeutic and immune boosting agent. *
The following is just a few examples of the many physiological and holistic benefits of PPC administration and how it structurally and functionally works to improve cell membrane metabolism and good health. * 
- PPC is a high energy structural and functional element of all biological membranes (e.g. of cells, blood corpuscles, lipoproteins, and surfactants
- PPC is indispensable for cellular differentiation, proliferation, repair, and regeneration
- PPC is important for the transport of molecules (nutrients and metabolic by products) through cell membranes
- PPC controls membrane-dependent metabolic processes between the intracellular and intercellular space
- PPC maintains and promotes the activity and activation of membrane-bound proteins such as of enzymes (e.g. Na+-K+-ATPase, lipoprotein lipase) and of receptors (e.g. of insulin)
- PPC contains polyunsaturated fatty acids to be used on request as precursors of cytoprotective prostaglandins and of other eicosanoids
- PPC contains choline to be used on request in certain neurological processes such as for the synthesis of the neurotransmitter acetylcholine
- PPC is a source of second messengers in cell signaling (e.g. of diacylglycerol)
- PPC contains phosphate e.g. for ATP formation
- PPC participates in fat emulsification in the GI-tract and in the bile
- PPC codetermine erythrocyte and platelet aggregation
- PPC restores depleted S-adenosylmethionine levels to normal and increases glutathione production in the liver
- PPC influences immunological reactions on the cellular level
The Role of PPC in the Immune System: *
The body has several ways in which to defend itself against infectious agents or pathogens. There are components of our bodily defenses that are not part of the Immune System such as our skin, which acts as an external barrier to pathogens. And there are internal barriers such as the mucous barriers that are found in our pulmonary and gastrointestinal systems.
Additionally, there are cells within our circulatory system that also defend against infectious agents and may be divided in to immune and non-immune cells depending on their origin. Nonetheless, both types may interact in a synergistic manner to “kill” or destroy the infectious agent or the infected cell.
One cell type that Purified Polyenyl-phosphatidylcholine has been shown to activate, or to enhance its “killing” ability is the Polymorphonuclear Leukocyte, a non-immune cell type. These cells are critical component of our “Innate” defense systems. They play an important role in defending against and succumbing to opportunistic infections to which individuals with suppressed and/or altered immune functions weakened by age, malnutrition, illness or by drugs being used to treat other various illnesses may be susceptible. 
Opportunistic infections are those caused by infectious pathogens (e.g., fungal, bacterial or viral) that are more likely to occur in those who may be chronically ill, or who are on medications that suppress their host defenses or immune responses. Host defenses include the skin, mucous membranes of our mouth, lungs, and gastrointestinal tract as well as certain cells circulating in our blood stream including polymorphonuclear leukocytes or PMNS. 
As stated earlier, Purified Polyenyl-phosphatidylcholine has been shown to “activate” certain cells of the immune system including those that can produce antibodies and others (Natural Killer (NK) Cells) that can “kill” infected cells (NK Cell Activity). 
According to Vitale, PPC is the preferred phosphoglyceride for activating positive immunological responses and what makes it an effective therapeutic and prophylactic agent for bacterial, yeast protistan and viral infections. 
Liver Immunobiology and the Importance of PPC in Liver Health and Function. *
Experimental and clinical results support the assumption that the therapeutic application of PPC has protective and even curative and regenerative effects on the biological membranes of sinus endothelial cells and liver cells.
The hepatoprotective effects of PPC have been confirmed when compared to controls and were more pronounced the earlier EPL was administered: 
- Structures of liver cell membranes were normal or largely normalized
- Fatty infiltrations and hepatocyte necrosis were diminished or eliminated
- Positive corresponding data were found for lipid peroxidation, transaminase and cholinesterase activity, and for serum lipids; and overall liver cell metabolism increased
- The increase of RNA and protein synthesis and of the liver cell glycogen content indicated a stimulation of the liver cells
- Reduced collagen production, collagen/DNA ratio and liver hydroxyproline indicated a reduced formation of connective tissue
- Click here to learn more about how PPC can improve liver health.
Liver Involvement in Adaptive Immunity
The liver is responsible for several important functions in innate and adaptive immunity. Contributions to the innate immune system include production of acute phase proteins, nonspeciﬁc phagocytosis of particles, nonspeciﬁc pinocytosis of molecules, and nonspeciﬁc cell killing. Hepatic involvement in innate immunity contributes to the systemic response to local inﬂammation, clearance of particles and soluble molecules from the circulation, and killing of invading cells such as neoplastic cells. Liver involvement in the adaptive (speciﬁc) immune system includes deletion of activated T cells, induction of tolerance to ingested and self-antigens, extrathymic proliferation of T cells, and deletion of many of the signaling and effector molecules. Hepatic involvement in adaptive immunity allows clearance of activated T cells and signaling molecules following inﬂammatory reactions and promotes immunologic tolerance toward potentially antigenic proteins that are absorbed from the intestinal tract. The liver is a major site of extrathymic T cell development, which assumes increasing signiﬁcance with aging in mammals. Perturbations in hepatic structure or function can result in signiﬁcant ramiﬁcations in both the innate and adaptive immune systems. 
In addition to serving as an arena for several immune-mediated pathologic processes, the normal liver has continual direct involvement in adaptive immune system. Major facets of this involvement consist of the:
- Deletion of activated T cells that originate from inflammatory reactions at any site in the body
- Induction of tolerance to ingested and self-antigens
- Extrathymic proliferation of T lymphocytes
- Disposal of waste molecules that result from immunologically mediated events. The major cellular elements involved in these processes include dendritic cells, macrophages, and various subpopulations of T lymphocytes. 
PPC Is Critical to Life and Optimal Wellness*
PPC is an essential and holistic molecule with many benefits, including improved immune function. Clinical trials and experimental studies have demonstrated conclusively that PPC as a membrane therapeutic effectively reactivates and improves liver cell metabolism and alters the lipid composition of certain immune cells, resulting in enhanced host defenses (phagocytosis and NK cell activity).
The discovery that the administration of PPC leads to a series of complex mechanisms triggering NK Activity and the enhancement of phagocytosis and “killing” by PNMs is significant. This discovery has led researchers to conclude that “clearly the dramatic effect of PPC on the clinical course and outcome of both bacterial and viral infections empirically demonstrates the use and value of PPC and related molecules as effective therapeutic and prophylactic agents for bacterial, yeast protist and viral infections. “ 
- Joseph J. Vitale, Prevention and Treatment of Microbial Infection by Phophoglycerides, US Patent: 5,135,922, 1992
- Karl J. Gundermann, The Essential Phospholipids As A Membrane Therapeutic, Polish Section of European Society of Biochemical Pharmacology, SZCZECIN, 1993
- George A. Parker and Catherine A. Picut – Liver Immunobiology, USA Toxicologic Pathology, 33:52–62, 2005
The Information Contained Herein is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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